The only contraindications are known hypersensitivities to erenumab, latex, rubber, or any of the inactive ingredients in the injection. In all cases, use a new autoinjector, and call 1-800-77-AMGEN (1-800-772-6436). 2017: Pages 425-434. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. A healthcare provider injects an antigen protein into a person and their body develops antibodies to those proteins. Compared to topiramate, new research indicates Aimovig is generally more effective and has fewerside effects. Important: Needle is inside the yellow safety guard. "Aimovig is a new treatment, and there are still many unanswered questions about safety," explains Dr. Burch. It's worth reading the fine print for your plan, however. Once you have used the dose, place the autoinjector or syringe in a puncture-proof "sharps" container. Women who are breastfeeding should talk to a healthcare provider about the pros and cons of taking Aimovig while breastfeeding. Belbuca costs $472 without insurance. (2019, March). so what if this scares you? Resolving this question will require a few more years of use. Last updated on Feb 16, 2022. I. As with any prescription drug, if too much Aimovig is taken, seek emergency treatment or call a poison helpline. Call your HCP or get emergency medical help right away if you have any of the following symptoms of an allergic reaction: swelling of the face, mouth, tongue or throat, or trouble breathing. Even so, following a few tips can both minimize side effects and maximize the benefits of Aimovig treatment. After removing Aimovig from the refrigerator, it can be stored at room temperature between 68F to 77F (20C to 25C) for up to 7 days. Aimovig: Highlights of Prescribing Information. Do not use the autoinjector after the expiration date on the label. Your doctor should monitor you for constipation and manage it as needed. Do not remove the orange cap from the autoinjector until you are ready to inject. Drugs that can raise blood pressure include, and ergot drugs), stimulants (including caffeine), nonsteroidal anti-inflammatory drugs (. (2019, June 24). However, most healthcare providers and insurance companies want patients to try topiramate and other first-line drugs such asnortriptylinebefore the newer medications. All About NSAIDs Such As Ibuprofen For Migraine Pain -- Migraine Again, Are Imitrex Side Effects Worth Its Benefits? Aimovig comes in 2 different types of devices: a single-dose (1 time) prefilled autoinjector or a single-dose (1 time) prefilled syringe. -- choose one answer. Put the used Aimovig autoinjector and orange cap in a FDA-cleared sharps disposal container right away after use. This can dry out the medicine. These peptides are responsible for blood vessel dilation and inflammation. Many already had pre-existing hypertension or risk factors for hypertension. If there is blood, press a cotton ball or gauze pad on your injection site. Although effective at reducing the number of migraine days each month, Aimovig may cause certain side effects, which may be worsened by pre-existing conditions or drug interactions. Do not put the autoinjector back in the refrigerator after it has reached room temperature. This is not a complete. Do not remove the orange cap from the autoinjector yet. Clean your injection site with an alcohol wipe. Constipation with serious complications. If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. This can dry out the medicine. : Drugs that treat diarrhea slow down intestinal activity, allowing waste products to remain longer in the bowels. I guess it's pretty straight forward but I've noticed that the more I take it, the more the injections hurt but I've also thought about it and Some cases of hypertension were severe enough to require hospitalization. The same thing may happen with monoclonal antibody drugs. Do not try to warm the autoinjector by using a heat source such as hot water or microwave. Contact your healthcare provider if you have an increase in blood pressure. Immunogenicity is exactly how many vaccines work. These are all signs of a possible allergic reaction. Do not remove the white cap from the autoinjector yet. Aimovig is only injected once a month in the upper arms, thighs, or abdomen. Clinical study results have established the efficacy and safety profile of Aimovig across a spectrum of people living with both episodic and chronic migraine. He also consults with Lilly, the maker of Emgality, and companies making other treatments mentioned in this article. Aimovig was the first FDA-approved preventive treatment for migraine in a new class that works by blocking the activity of calcitonin gene-related peptide (CGRP). This adverse effect is more likely to occur in people who already have high blood pressure or risk factors for high blood pressure. Allergic to rubber or latex. To avoid injection site reactions, dont be hasty when giving an injection. Although there is not a specific warning against consuming alcohol with Aimovig, alcohol may trigger or worsen a migraine headache in many people, especially red wine, beer, and hard liquor. Immunogenicity is exactly how many vaccines work. Keep your skin stretched or pinched while injecting. There have been reports of people developing high blood pressure or a worsening of their high blood pressure, most frequently within 7 days of administration. This can happen within hours to days after using Aimovig . This has prompted the FDA to update the warnings and precautions label of Aimovig to reflect the risk of more severe constipation. | Warnings | Interactions | How to avoid side effects | Resources. In addition, many patients taking Aimovig were able to reduce their monthly migraine days by 50% or more, compared to 24% (chronic migraine group) to 27% (episodic migraine group) of those taking the placebo. The autoinjector should be kept in the refrigerator at 36F to 46F (2C to 8C). It is normal to see a drop of liquid at the end of the needle or green safety guard. There may be state or local laws about how you should throw away used needles and syringes. Keep the syringe out of the reach of children. Neither the liver nor the kidneys are involved in breaking down or eliminating erenumab, so people with kidney disease or liver impairment can take Aimovig at normal doses. These are not all of the possible side effects of Aimovig. Neither the manufacturer, Amgen, nor the FDA has reported Aimovig overdoses or possible side effects of an overdose. Copyright 1996-2023 Drugs.com. Aimovig belongs to the class of medicines known as CGRP inhibitors. Do not take extra doses, do not skip doses, and do not stop this medication until talking to a healthcare professional. Allergic reactions, including rash or swelling can happen after receiving Aimovig . Do not freeze or use the autoinjector if it has been frozen. Some required treatment and hospitalization. Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. This is most likely because of the high cost associated with Aimovig. Migraine patients who experience hair loss should talk to their prescribing healthcare provider and consider alternative antibody therapies or other migraine prevention drugs, such as Topamax (topiramate)if hair loss is a problem. Do not use the autoinjector if the autoinjector has been dropped. Storing your Aimovig SureClick autoinjector. Pregnant or plan to become pregnant. Do not put the gray needle cap back onto the syringe. They're designed to take for migraine attacks. Revision date: February 16, 2022. The U.S. Food and Drug Administration (FDA) has not approved the use of Aimovg in children. Erenumab binds to the CGRP receptor and prevents it from interacting with CGRP. Animal studies have shown no evidence that Aimovig will harm a fetus. what happens if aimovig gets warm. If your insurance plan does not cover Aimovig, you have the option of filing an appeal, also known as a formulary exemption. Aimovig is an injectable migraine medicine in the class of drugs known as CGRP inhibitors. Constipation was reported in up to 3% of people receiving Aimovig 140mg in clinical trials (reported in 1% with the 70mg dose). The needle shield within the orange cap of the Aimovig autoinjector contains dry natural rubber, which is made from latex. Dont heat it in any way, just let the ambient room temperature warm it up. Wash your hands thoroughly with soap and water. Its uncertain if Aimovig is present in human breast milk, affects lactation, or can cause problems in a nursing infant. This list will help both the prescribing healthcare provider and pharmacist prevent possible drug interactions. Apply an adhesive bandage if needed. Before you inject, always check the label of your single-dose prefilled autoinjector or single-dose prefilled syringe to make sure you have the correct medicine and the correct dose of Aimovig. Then lift your thumb while still holding the autoinjector on your skin. Injection site reactions and constipation are the most common side effects but it has no reported drug interactions. Updated 11/2021. There is no one-size-fits-all migraine treatment. Migraine patients who experience hair loss should talk to their prescribing healthcare provider and consider alternative antibody therapies or other migraine prevention drugs, such as Topamax (, Monoclonal antibodies often carry a risk for immunogenicity, in which the body develops an immune response against the monoclonal antibody. Important: You must push all the way down but do not touch the gray start button until you are ready to inject. When you are ready to inject, press the gray start button. Important: When you remove the syringe, if it looks like the medicine is still in the syringe barrel, this means you have not received a full dose. If you are considering Aimovig to prevent migraine, having accurate, up-to-date information on the medication is key. When asked if patients will have to take Aimovig forever, Dr. Gottschalk said, "Probably not. Aimovig is not metabolized by cytochrome P450 enzymes; therefore, interactions with concomitant medications that are substrates, inducers, or inhibitors of cytochrome P450 enzymes are unlikely. Aimovig is a brand-name prescription drug taken as a once-monthly injection to prevent episodic or chronic migraine headaches. Using other medications that can cause constipation may increase your risk for more severe constipation and constipation-related complications. Tell your healthcare provider if you are allergic to latex. Aimovig may even worsen headache. Allergic reactions, including rash or swelling can happen after receiving Aimovig . A. Dodick, D. W., Ashina, M., Brandes, J. L., Kudrow, D., Lanteri-Minet, M., Osipova, V., Lenz, R. A. A severe allergic reaction or severe constipation with serious complications may require medical treatment and take several days or weeks to get better. In some cases, people have been hospitalized or needed surgery. In clinical studies, hair loss was experienced by only, . Do not touch this area again before injecting. (2018, December 10). Single-Dose Prefilled SureClick Autoinjector 70 mg/mL, Single-Dose Prefilled SureClick Autoinjector 140 mg/mL, Single-Dose Prefilled Syringe 70 mg/mL And 140 mg/mL. Aimovig is a prescription medicine that can be self-injected under the skin once a month to prevent migraine headaches in adults. such as aspirin or ibuprofen), decongestants, birth control pills, corticosteroids, and some herbal supplements. Some of the people had high blood pressure before starting treatment with Aimovig, but others did not. "This finding isn't surprising," says Dr. Burch. The incidence is unknown (the Prescribers Digital Reference puts the incidence at, ) and some healthcare professionals are uncertain if Aimovig is the primary cause. (2018). Mild side effects of Aimovig that have been reported include: muscle spasms (muscle tightening that you can't control) or cramps mild constipation * reactions at injection sites* Mild side. Aimovig can increase blood pressure, so people diagnosed with hypertension or with any of the risk factors for high blood pressure will need to have their blood pressure monitored regularly while taking Aimovig. Some plans cover only 50% of the total cost until you meet your deductible, which still leaves you on the hook for ~$300 per month for Aimovig. Much Aimovig is a new treatment, and there are still many unanswered questions about safety, '' Dr.. 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